STIAS Lecture Series 2017: Carlos Ibanez – Dementia: clinical overview and preclinical research

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Date/Time
17/10/2017
13:00 - 14:00
Location
Van der Sterr Building, Room 2121
Category(ies)

 

Please note the new venue for STIAS Public Lectures: Room 2121, 2nd floor, Van der Sterr Building  (use entrance 1 opposite the CGW Schumann Building).

Professor Carlos Ibanez, Professor of Neuroscience at the Karolinska Institute, Stockholm and STIAS fellow will present a talk with the title:

 

Dementia: clinical overview and preclinical research

Carlos IbanezSTIAS Fellow Carlos Ibanez

Abstract

Prosperous populations live longer and old age carries a high risk of dementia, a condition that is so far neither preventable nor curable. The trend of incidence of Alzheimer’s Disease (AD), the most common form of dementia, is increasing all over the world. AD is widely thought to be driven by amyloid pathology, in which peptides of amyloid-β are generated in the brain and clump together into plaques. Another form of dementia with similar symptoms, generally known as vascular dementia, is driven by vascular pathology. Vascular dementia is one of the most common causes of dementia after AD. The relationship between AD and vascular dementia is complex, and there is likely a continuum, with most cases displaying some features of both conditions.

Several studies performed in Asian populations have found a high prevalence of cerebrovascular disease in cognitive impaired and AD patients. These and other results suggest that the prevalence of different types of dementias may be region-specific and thus different in different world populations. Few studies to determine the prevalence of dementia have been conducted in sub-Saharan Africa. A systematic review of studies reporting the prevalence of dementia and cognitive impairment among older black Africans in sub-Saharan Africa countries was conducted in 2013 and found prevalence’s varied widely between countries. The predominant factors associated with a higher prevalence of dementia were older age and female sex, and similar associations have been reported globally. There is a paucity of published research on the prevalence of dementia in South Africa.

This lecture will present a quick overview of dementia incidence in the world and in South Africa, and review some of our current knowledge of the different types of dementia and underlying causes. I will also present some of the ongoing preclinical research work done at my laboratory using animal models of AD, and how several AD manifestations can be alleviated in these models by manipulation of other genetic factors.

Carlos Ibanez studied biology at the University of Buenos Aires, Argentina. His PhD work was conducted at the Leloir Institute. Carlos Ibanez did postdoctoral studies at the Karolinska Institute in Stockholm, Sweden. In 1996, he became Professor in Neuroscience at the same institute. Since 2012, he has a double appointment as Professor at the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. Carlos Ibanez is member of the Nobel Assembly and Nobel Committee for Physiology or Medicine at the Karolinska Institute, member of the European Molecular Biology Organization EMBO, and a Scholar of the Wallenberg Foundation of Sweden.

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