A growing concern in HIV research is the emergence of drug resistant strains of the virus. This could have far-reaching consequences for treatment strategies and the government’s ARV plan. The dynamics between host and virus and the factors contributing to drug resistance are not adequately understood. The project will use analytical and numerical methods on appropriately crafted models to obtain new levels of understanding regarding the host-viral dynamics. The project is a joint undertaking with SACEMA (see below the section on special programmes).