Patients with homozygous beta thalassemia have complex clinical complications due to the need for blood transfusions and iron overload. Liver pathology due to the latter and a high prevalence of hepatitis C infections is a major problem and can result in cirrhosis and/or hepatocellular carcinoma. Early detection of fibrosis plays an essential role in the management of these patients. Fibroscan has been shown to be a sensitive, specific and non-invasive method to detect early fibrosis. However, there are conflicting reports on the effect of liver iron on liver stiffness. This retrospective study on a cohort of thalassemia major patients at Sultan Qaboos University Hospital, Oman, using shear wave elastography, aims to clarify the relationship between liver stiffness, HCV positivity and chronic iron overload.