You are here:

Project:

Treatment of Hepatitis C virus in Oman: a multicenter study

Unlike Hepatitis B, there is no vaccine available for protection against Hepatitis C virus (HCV).  Multi transfused patients eg patients with sickle cell disease and thalassaemia were at particular risk until the early 1990’s as there was no donor screening test available till then. Thus, many older patients have HCV infection.  Chronic HCV infection can lead to liver cirrhosis and possibly hepatocellular cancer.  Treatment of HCV has been extremely difficult; however, recently, a new class of agents termed ‘direct acting antivirals’ (DAAs) have been developed and used and have shown remarkable effectiveness.

We have just started a retrospective study of HCV treated patients, treated with both the older group of drugs (Alfa interferon + Ribavirin) and also patients treated with the newer DAAs. This is a multicenter study of a large cohort of Omani patients, seen at the Armed Forces Hospital and Sultan Qaboos University Hospital. The total numbers are >400.  This would be the largest report from the Middle East.  The cohort would include sub groups of patients with thalassaemia and sickle cell disease.

During my time at STIAS,  I plan to  review the available literature and work out a plan for the eventual manuscript. The data is already available and is being collated.

 

Fellows involved in this project

Visiting scholar
Oman
 
 

Related publications

Journal Article

De Sanctis, Vincenzo, Ashraf T Soliman, Heba Elsedfy, Alice Albu, Soad Al Jaouni, Salvatore Anastasi, Maria Grazia Bisconte, Duran Canatan, Soteroula Christou, Shahina Daar, Salvatore Di Maio, Mohamed El Kholy, Doaa Khater, Mohamed Elshinawy, Yurdanur Kilinc, Roberto Mattei, Hala H Mosli, Alessandra Quota, Maria Grazia Roberti, Praveen Sobti, saif AL Yaarubi, Saveria Canpisi and Christos Kattamis. 2016. The ICET-A Recommendations for the Diagnosis and Management of Disturbances of Glucose Homeostasis in Thalassemia Major Patients. Mediterranean Journal of Hematology and Infectious Diseases 8:e2016058. http://www.mjhid.org/index.php/mjhid/article/view/2016.058

Journal Article

De Sanctis, Vincenzo, Ashraf T Soliman, Heba Elsedfy, Alice Albu, Soad Al Jaouni, Salvatore Anastasi, Maria Grazia Bisconte, Duran Canatan, Soteroula Christou, Shahina Daar, Salvatore Di Maio, Mohamed El Kholy, Doaa Khater, Mohamed Elshinawy, Yurdanur Kilinc, Roberto Mattei, Hala H Mosli, Alessandra Quota, Maria Grazia Roberti, et al. 2016. Review and Recommendations on Management of Adult Female Thalassemia Patients with Hypogonadism based on Literature Review and Experience of ICET-A Network Specialists. Mediterranean Journal of Hematology and Infectious Diseases 9(1):e2017001. http://www.mjhid.org/index.php/mjhid/article/view/20017.001

Journal Article

Norris, Shane A., Abdallah Daar, Dorairajan Balasubramanian, Peter Byass, Elizabeth Kimani-Murage, Andrew Macnab, Christoff Pauw, Atul Singhal, Chittaranjan Yajnik, James Akazili, Naomi Levitt, Jihene Maatoug, Nolwazi Mkhwanazi, Sophie E. Moore, Moffat Nyirenda, Juliet R. C. Pulliam, Tamsen Rochat, Rihlat Said-Mohamed, Soraya Seedat, Eugene Sobngwi, Mark Tomlinson, Elona Toska, Cari van Schalkwyk. 2017. Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations. Global Health Action, 10(1), 1334985. https://doi.org/10.1080/16549716.2017.1334985

Journal Article

De Sanctis, Vincenzo, Ashraf T Soliman, Duran Canatan, Ploutarchos Tzoulis, Shahina Daar, Salvatore Di Maio, Heba Elsedfy, Mohamed A Yassin, Aldo Filosa, Nada Soliman, Mehran Karimi, Forough Saki, Praveen Sobti, Shruti Kakkar, Soteroula Christou, Alice Albu, Constantinos Christodoulides, Yudanur Kilinc, Soad Al Jaouni, Doaa Khater, Saif A Alyaarubi, Su Han Lum, Saveria Campisi, Salvatore Anastasi, Maria Concetta Galati, Giuseppe Raiola, Yasser Wali, Ihab Z Elhakim, Demetris Mariannis, Vassilis Ladis and Christos Kattamis. 2018. An ICET-A survey on occult and emerging endocrine complications in patients with β-thalassemia major: Conclusions and recommendations. ACTA BIOMEDICA, 89(4), 481–489. https://doi.org/10.23750/abm.v89i4.774

Journal Article

Al-Riyami, Arwa Z. and Shahina Daar. 2018. Transfusion in Haemoglobinopathies: Review and recommendations for local blood banks and transfusion services in Oman. Sultan Qaboos University Medical Journal [SQUMJ], 18(1), 3. https://doi.org/10.18295/squmj.2018.18.01.002

Journal Article

Al-Khabori, Murtadha, Shahina Daar, Said A Al-Busafi, Humoud Al-Dhuhli, AlGhalya A Alumairi, Moez Hassan, Sara Al-Rahbi and Umaima Al-Ajmi. 2019. Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography. Hematology, 24(1), 183–188. https://doi.org/10.1080/10245332.2018.1540518

Share this project:

Share on whatsapp
WhatsApp
Share on email
Email
Share on facebook
Facebook
Share on twitter
Twitter
Share on linkedin
LinkedIn

Is any information on this page incorrect or outdated? Please notify Ms. Nel-Mari Loock at [email protected].