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Blood clotting in disease: The role of blood flow – STIAS webinar by Malebogo Ngoepe

STIAS Public Lectures Series

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Register here by 17 March 2021

 

Malebogo Ngoepe associate professor in the Department of Mechanical Engineering at the University of Cape Town and STIAS Iso Lomso fellow will present a webinar with the title:

Blood clotting in disease: The role of blood flow

Abstract

Thrombosis, or blood clot formation, is an important feature of many vascular diseases. This process is influenced by a wide range of variables, including biochemical reactions and blood flow. Many of the breakthroughs in our current understanding of blood clots have been led by the biochemistry and physiology communities, and have enabled a sophisticated appreciation of the process. The addition of haemodynamics, or blood flow, is a relatively recent development and can contribute to our understanding of blood clot formation in disease. Computational and experimental flow techniques, which are commonly used in the study of fluid flows in more traditional engineering contexts, can be translated to medical and biological applications. Computational fluid dynamics (CFD), for example, is an important technique for the development of computational thrombosis models. In this lecture, we will explore how the incorporation of flow enables insight into blood clotting in particular diseases, including brain aneurysms and COVID-19.

Malebogo Ngoepe is an associate professor in the Department of Mechanical Engineering at the University of Cape Town. Her research focuses on applying mechanics to biological and medical topics, including thrombosis, congenital heart disease and curly hair. She read for a DPhil in Engineering Science at the University of Oxford as a Rhodes Scholar. She currently serves as the secretary for the South African Association of Theoretical and Applied Mechanics.

For more information, contact Ms Nel-Mari Loock at 021 808 2652 or [email protected]

Date and time

Thursday, 18 March 2021

15:45 – 17:30​

All times are in SAST (UTC+2)

Location

Online

Wallenberg Research Centre
Stellenbosch

Related to this event

Fellows

Iso Lomso Fellow
South Africa

Projects

Thrombosis is closely linked to aneurysm evolution. In some cases, the presence of a clot can accelerate the time to aneurysm rupture while in others, it can stabilise the aneurysm and prevent rupture....

Publications

Journal Article

Ngoepe, Malebogo N., Alejandro F. Frangi, James V. Byrne and Yiannis Ventikos. 2018. Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review. Frontiers in Physiology, 9. https://doi.org/10.3389/fphys.2018.00306

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