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Computational modelling of tubular fibrous scaffold Structures for cardiovascular graft applications: parametric modelling, and Finite Element Analysis.

Cardiovascular diseases cause most deaths worldwide, treatment involves use of biological vascular scaffolds, due to their capability of providing sufficient structural and biological support to tissues. In spite of these favourable attributes and recent improvements to their mechanical properties, porosity, and bio-activity, there is still limitations in polymeric scaffolds design and fabrication in terms of: polymer assembly, surface topography, nano-/macro- structure, bio-compatibility, biodegradability, directing cell function and induced formation of natural tissue. There is need for in-depth investigation of their performance to further support their seamless integration as vascular implants. this project aims to use computational modelling to design polymeric scaffolds. The in-vitro performance of the prototypes will be simulated using 3D models of vascular scaffolds using parametric modelling. In this regard, python® language platform in pyFormex® will be used to create the 3D models. A Finite Element Analysis (FEA) platform will be adopted for stress strains analysis and mechanical deformation studies of the prototypes which will be accomplished using realistic boundary conditions to simulate deployment and performance vascular scaffolds; and experiments designed for validation and calibration of the simulations.


Fellows involved in this project

Iso Lomso Fellow

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Is any information on this page incorrect or outdated? Please notify Ms. Nel-Mari Loock at [email protected].