In Benin, the preliminary studies showed that the leafy vegetables produced in southern Benin were contaminated with C. jejuni and C. coli and that the origin of this contamination was the contaminated poultry manures used by market gardeners to make the soil fertile. Also, this study showed that chicken sold in markets of southern Benin were also contaminated with both C. jejuni and C. coli strains that are multidrug resistant. In addition, one study showed that strains of Salmonella spp. isolated from poultry droppings in Benin were virulent and multidrug-resistant. These results lead us to ask the following research questions: What is the epidemiological situation and the genomic link of multidrug resistant strains of Campylobacter and non-typhoid Salmonella between animals, environment and humans in poultry farms in Benin? How to fight against antibiotic resistance for better biocontrol of Campylobacter and non-typhoidal Salmonella strains on these farms? It is to answer of both research questions that this study is initiated. It aims to study the genomic surveillance of multidrug-resistant Campylobacter and non-typhoidal Salmonella strains isolated from animals, environment, and workers on poultry farms in Benin and to develop cocktail of bacteriophages effective against these strains.