This project aim to study mechanisms underlying the very high occurrence of type 2 diabetes in black South African Women. This can be possible via collected blood samples from a unique cohort of women that were caregivers to the Birth to Twenty Plus cohort, originally recruited in Soweto-Johannesburg 1990. In addition, we have performed an exercise training program among obese black South African Women. The blood samples in the first study sample will be analyzed with advanced biochemical methods – metabolomics and lipidomics – in order to find specific markers in the blood for increased diabetes risk. In the second study part we have done extensive analyses of body composition including measures of fat within different organs, analyses of the body sensitivity to insulin and also collected samples from fat and muscle before and after training. We hope to find important determinants of type 2 diabetes via analyses of the effects of exercise training in this high-risk group for later development of diabetes.
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Project:
Prediction and reversibility of insulin resistance and type 2 diabetes in black South African women
Related publications
Kufe, Nyuyki Clement, Maphoko Masemola, Tinashe Chikowore, Andre Pascal Kengne, Tommy Olsson, Julia H. Goedecke and Lisa K. Micklesfield. 2019. Protocol for systematic review and meta-analysis of sex hormones and diabetes risk in ageing men and women of African ancestry. BMJ Open, 9(1), e024446. https://doi.org/10.1136/bmjopen-2018-024446
Mtintsilana, Asanda, Lisa K. Micklesfield, Elin Chorell, Tommy Olsson and Julia H. Goedecke. 2019. Fat redistribution and accumulation of visceral adipose tissue predicts type 2 diabetes risk in middle-aged black South African women: a 13-year longitudinal study. Nutrition & Diabetes, 9(1), 12. https://doi.org/10.1038/s41387-019-0079-8
Zeng, Yingxu, Asanda Mtintsilana, Julia H. Goedecke, Lisa K. Micklesfield, Tommy Olsson, Elin Chorell. 2019. Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black South African women: a prospective cohort study. Metabolism, 95, 57–64. https://doi.org/10.1016/j.metabol.2019.04.001
Mtintsilana, Asanda, Lisa K. Micklesfield, Elin Chorell, Tommy Olsson, Nitin Shivappa, James R. Hebert Andre P. Kengne and Julia H. Goedecke. 2019. Adiposity Mediates the Association between the Dietary Inflammatory Index and Markers of Type 2 Diabetes Risk in Middle-Aged Black South African Women. Nutrients, 11(6), 1246. https://doi.org/10.3390/nu11061246
Nono Nankam, Pamela A., Paul J. van Jaarsveld, Elin Chorell, Melony C. Fortuin-de Smidt, Kevin Adams, Matthias Blüher, Tommy Olsson, Amy E. Mendham and Julia H. Goedecke. 2020. Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study. Nutrients, 12(6), 1619. https://doi.org/10.3390/nu12061619
Fortuin-de Smidt, Melony C., Amy E. Mendham, Jon Hauksson, Olaf Hakim, Darko Stefanovski, Louise Clamp, Lindokuhle Phiri, Jeroen Swart, Louise M Goff, Lisa K. Micklesfield, Steven E. Kahn, Tommy Olsson and Julia Goedecke. 2020. Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women: a randomized controlled trial. European Journal of Endocrinology, 183(1), 51–61. https://doi.org/10.1530/EJE-19-0957
Goedecke, Julia H. and Tommy Olsson. 2020. Pathogenesis of type 2 diabetes risk in black Africans: a South African perspective. Journal of Internal Medicine, 288(3), 284–294. https://doi.org/10.1111/joim.13083
Goedecke, Julia H., Elin Chorell, Paul J. van Jaarsveld, Ulf Risérus and Tommy Olsson. 2021. Fatty Acid Metabolism and Associations with Insulin Sensitivity Differs Between Black and White South African Women. The Journal of Clinical Endocrinology & Metabolism, 106(1), e140–e151. https://doi.org/10.1210/clinem/dgaa696
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