Comparative computational study of thrombosis in cerebral and abdominal aortic Aneurysms

Thrombosis is closely linked to aneurysm evolution. In some cases, the presence of a clot can accelerate the time to aneurysm rupture while in others, it can stabilise the aneurysm and prevent rupture. The few computational models that simulate aneurysm thrombosis have focused on either cerebral aneurysms or on abdominal aortic aneurysms. The aim of these models   has   been   to   predict   thrombosis   outcome following intervention,   or   to   better understand the processes at play during aneurysm thrombus formation. In this work, a joint thrombosis model which can be applied in both cerebral aneurysms and abdominal aortic aneurysms is proposed. It is thought that such an approach will be useful for elucidating clotting features which are common to both pathologies, and highlighting the key differences. This information will be useful for disease management and therapeutic approach. In my previous work, I have developed a computational model of thrombosis in cerebral aneurysms. In   this   work,   I   would   like   to   extend   this   model   to   abdominal   aortic   aneurysms   in collaboration with partners from KTH Stockholm, Sweden. Their experience in general abdominal aortic aneurysm modelling will be invaluable for modelling thrombosis in this specific pathology.

Project leader(s):
  • Malebogo Ngoepe (Department of Mechanical Engineering, University of Cape Town)

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